Additionally, treatment with both 740 Y-P and oe-PTEN was found to increase glucose uptake, acetyl-CoA synthesis, lactate production, ECAR, and decrease OCR compared to oe-PTEN treatment alone in HHCC cells (Fig. 5b, c), suggesting activation of the PI3K pathway reprogramed HCC cell metabolism even in the presence of PTEN. The gene discussed is PTEN; the disease is hepatocellular carcinoma.