We characterized a total of 12 ACE2 putative deleterious missense variants, whereas the top variants with functional disruptions predicted by all tools included p.Leu731Phe (rs147311723, AF = 0.01 in African), p.Arg219Cys (rs372272603, AF = 7 × 10−4 in European), p.Ser547Cys (rs373025684, AF = 4 × 10−4 in European) and p.His378Arg (rs142984500, AF = 2 × 10−4 in European) (Table 1). This evidence concerns the gene ACE2 and atrial fibrillation.