Further analysis if the amount of secreted IGFBP-3 was in parallel with that of intracellular IGFBP-3 to dissect the spatio-temporal function of IGFBP-3 would be important for in depth understanding how IGFBP-3 contributes in cell growth inhibition in patients with prostate cancer. The gene discussed is IGFBP3; the disease is prostate cancer.