HEBP2 and insomnia measurement: Figure 4 demonstrated that these identified insomnia-risk genes is generated a biological network, suggesting that there exist highly functional links among these identified risk genes. For example, two hub genes of LDHA and FGFR3 have the most interactions with other genes (Figure 4). Additionally, the gene of TEX264 shows evidence of shared protein domains with the insomnia-risk gene of HEBP2, and has co-expression evidence with DALRD3 (Figure 4).