For example, Newington and co-workers [84] have shown that the overexpression of LDHA in a rat B12 cell line conveys resistance to amyloid β and other neurotoxins, which may elucidate why some people tolerate high levels of amyloid β deposition without the development of Alzheimer’s disease. The gene discussed is LDHA; the disease is early-onset autosomal dominant Alzheimer disease.