For example, the top-ranked genes of FOXF2 (simulated P=8.89 × 10−6), FAM193A (simulated P=1.22 × 10−4), PAIP1 (simulated P=3.33 × 10−4), MPG (simulated P=3.67×10−4), INO80 (simulated P = 5.00 × 10−4), VPS13B (simulated P = 8.89 × 10−6), and TGFB3 (simulated P = 8.89 × 10−6) with supportive eSNPs conveying risk to insomnia (Table 1). The gene discussed is TGFB3; the disease is insomnia.