Furthermore, by conducting a DGE analysis, we found that three genes of DALRD3 (P=5.0 × 10−5), LDHA (P=0.044), and HEBP2 (P=0.032) showed significantly down-regulated expression in insomnia brain samples compared with controls (Figure 5C–E and Supplementary Table S8). Here, HEBP2 is linked to insomnia measurement.