As is shown in Table 2, ceramides including Cer (d36:3), Cer (d34:2), Cer (d38:6), Cer (d36:4) and Cer (d16:0/18:1) were increased in LAA cerebrovascular disease than those in the control (P<0.05), suggesting that changes of ceramides may be present in LAA cerebrovascular disease. The gene discussed is CBLN1; the disease is cerebrovascular disorder.