PITX1 and malignant colon neoplasm: The tumorigenic effect of PITX1 gene was achieved by some signaling pathways, such as EMT and WNT/β-catenin signaling pathway that have a positive regulatory effect on proliferation and invasion in gastric cancer [15], while it was related to KRAS, WNT, NF-κB activation pathway and TGF-β signaling pathway in colon cancer [16].