Optic vesicle‐like structures derived from a microphthalmia patient with a VSX2 null variant (p.Arg200Gln) showed upregulation of WNT pathway components and misexpression of retinal pigment epithelium (RPE) markers at the expense of the neural retina (NR) lineage, which was rescued by pharmacological inhibition of WNT signaling (Capowski et al., 2016). Here, VSX2 is linked to microphthalmia.