HOXB13 and posterior cortical atrophy: A unique feature of this population-based study was that cancer cases were not selected based on clinical characteristics or family history; therefore, results are more applicable to the general population for developing broad genetic testing and counselling regarding HOXB13. The strong association of the G84E mutation and PCa risk (OR = 4.81) from this population-based study, together with the consistent finding from previously published studies, suggest this mutation be included in germline testing for assessing PCa risk for men in their thirties and forties.