HOXB13 was identified as a prostate cancer (PCa) susceptibility gene in 2012.1 A recurrent germline mutation (G84E) found exclusively in European descendants co-segregated with PCa diagnosis in families and presented at a significantly higher frequency in PCa patients (1.4%) compared to unaffected controls (0.1–0.4%) in the population. Here, HOXB13 is linked to prostate cancer.