It was shown that pharmacologically inhibiting cholesterol absorption (using ezetimibe) and PCSK9 activity (using evolocumab or alirocumab) constitute efficient options for modulating LDL-C metabolism in patients administered statin; indeed, combining statin and non-statin agents alleviates coronary atherosclerosis, with overt cardiovascular benefits in moderate-to-high cardiovascular risk individuals [35–37]. Here, PCSK9 is linked to coronary atherosclerosis.