An elegant study undertaken using MMTV-PyMT mice and organoids showed that, though loss of E-cadherin increased the invasive potential of tumour cells in three-dimensional invasion assays, transplantation of E-cadherin mutant tumour organoids into mice resulted in an almost-complete ablation of metastatic potential compared with their wild-type tumour counterparts [62]. Here, CDH1 is linked to neoplasm.