As a conserved miRNA, miR-378 is located in the first intron of peroxisome proliferator-activated receptor γ coactivator-1β (PGC-1β),12 and it is widely expressed in many tissues, including adipose, skeletal muscles, myocardium, etc. miR-378 was originally identified as an oncogene promoting vascular endothelial growth factor (VEGF) expression in human nasopharyngeal carcinoma;13 it was then proven to participate in a variety of biological processes, such as cancer metastasis and differentiation.14 This evidence concerns the gene VEGFA and cancer.