We tested whether: (i) genetic predisposition for T2DM is associated with risk of PEs and psychotic disorder at age 18; (ii) genetic predisposition for schizophrenia is associated with IR at age 18; (iii) whether these associations are mediated by CRP or IL-6 levels measured in childhood at age 9. The gene discussed is IL6; the disease is type 2 diabetes mellitus.