There was no evidence for a mediating effect of CRP on the association between PRS-schizophrenia and IR at age 18; the coefficients were 0.14; 95% CI, −0.06–0.34, p = .756 for direct effect; co-efficient = 0.01; 95% CI, −0.01–0.03, p = .180 for indirect effect. Here, CRP is linked to schizophrenia.