UBE2I and senile cataract: These results allow us to draw two conclusions: 1) Sumoylation is implicated in control of aging and cataractogenesis; and 2) Ubc9, SENP6, and Pax6 can be used as the molecular signature for senile cataracts, but the di‐sumoylated p46 Pax6 can be used as molecular signature for complicated cataracts.