SUMO2 and cataract: In the present study, we have demonstrated the following: (a) Sumoylation ligases are upregulated in cataract patients from 50s to 60s, remains at a high level in those from 60s to 70s, but all downregulated in those from 70s to 80s in comparison with that in 50s; (b) de‐sumoylation enzymes, SENPs, displayed differential changes among all enzymes in cataract patients from 50s to 80s; and (c) SUMO1‐ and SUMO2/3‐conjugated proteins are upregulated in cataract patients from 50s to 70s.