APOE and Alzheimer disease: Consistent with our previous study using AD subjects with severe CAA or without CAA,21 we confirmed that male sex and the APOE ε4 allele were significantly associated with a greater CAA score in multivariable analysis (all P ≤ .002 for analysis of all patients) in this larger AD cohort with a broad spectrum of CAA scores (Table S4; Figure S1 in supporting information).