For example, studies on breast cancer metastasis reported that overexpressed DR5 was able to improve the expression of C‐X‐C chemokine receptor type 4 (CXCR4) on the surface of MDA‐MB‐231 BCa cells, whose migratory potential towards stromal cell–derived factor 1 (SDF1) was subsequently enhanced.41 This evidence concerns the gene CXCL12 and breast cancer.