With the application of TUNEL and HE staining using the kidney tissue sampled from the sepsis‐associated AKI rat model, we confirmed that, in vivo, down‐regulation of SMG1 also led to increased levels of apoptosis and inflammation, and inhibition of miR‐9‐3p then led to alleviated phenotype (Figure 6J‐M). Here, SMG1 is linked to Sepsis.