With the application of TUNEL and HE staining using the kidney tissue sampled from the sepsis‐associated AKI rat model, we confirmed that, in vivo, down‐regulation of SMG1 also led to increased levels of apoptosis and inflammation, and inhibition of miR‐9‐3p then led to alleviated phenotype (Figure 6J‐M). The gene discussed is SMG1; the disease is acute kidney injury.