Our analysis identifies three non-HLA susceptibility loci (CCL24, STYXL1-SRRM3, and C1orf141-IL23R) for sarcoidosis and demonstrates the importance of genetic control of CCL24, POR, and IL23R, through genetic polymorphisms, in the pathogenesis of sarcoidosis. The gene discussed is STYXL1; the disease is sarcoidosis.