This led us to speculate that in CLL cells SLAMF1 and SLAMF7 receptors recruit PHB2 away from the IgM molecule thereby functionally inducing a PHB2 loss situation leading to impaired BCR signaling and the knockdown of PHB2 could not add up in this scenario. The gene discussed is SLAMF1; the disease is B-cell chronic lymphocytic leukemia.