Of all docked ginger phytochemicals, gingernone family molecules showed the highest binding affinity to FAS-TE domain (C form: − 7.5 kcal/mol, B form: − 7.4 kcal/mol and A form: − 7.1 kcal/mol) even higher than orlistat which is a US FDA-approved and marketed drug for management of obesity, acting through FAS-TE inhibition26 (Fig. 5, Fig. S3). Here, FAS is linked to obesity due to melanocortin 4 receptor deficiency.