Interestingly, the expression levels of autophagy-related proteins of LC3II (P < 0.01) and Atg5 were definitely increased (P < 0.001), while SQSTM1 were significantly decreased (P < 0.05) following the infection with ALV-J or the overexpression of GADD45β for 4 h in DF-1 cells or CEF cells. The gene discussed is ATG5; the disease is infection.