In a word, our work elucidated that LEF1-AS1 interacts with miR-489-3p to relieve the suppressing effect of miR-489-3p on HIGD1A mRNA so as to increase the expression of HIGD1A, thereby promoting cell proliferation and inhibiting apoptosis in glioma, evidencing that LEF1-AS1 might serve as a potential therapeutic target for glioma patients. This evidence concerns the gene LEF1 and central nervous system cancer.