Furthermore, we discovered that the inhibition effect of CRNDE knockdown on HCC proliferation and migration was compromised by the silencing of CELF2, whereas overexpression of human large tumor suppressor 2 (LATS2), the Hippo signal pathway kinase, could efficiently inhibit the oncogenic properties of CRNDE in HCC. This evidence concerns the gene LATS2 and hepatocellular carcinoma.