These results indicated the close interaction between CRNDE and EZH2/SUZ12/SUV39H1, which targeted directly the promoter loci of the tumor suppressor genes, and thus we reasoned that CRNDE might mediate epigenetic suppression of these proteins on multiple tumor suppressive genes by forming a complex with EZH2/SUZ12/SUV39H1, as well as the promoter regions of tumor suppressor genes. This evidence concerns the gene EZH2 and neoplasm.