Given the importance of PRC2 as a histone methyltransferase in HCC, we further investigated the interaction between CRNDE and EZH2, SUZ12, and SUV39H1, and found that the inhibitory effect of EZH2, SUZ12, and SUV39H1 on tumor suppressors was mediated by CRNDE. This evidence concerns the gene EZH2 and hepatocellular carcinoma.