LATS2 and neoplasm: It has been also shown that LATS2, the core kinase of Hippo pathway, functions as tumor suppressor gene in various cancers types, including leukemia67, breast cancer68, lung cancer69, and prostate cancer70 through the regulated phosphorylation of the transcription co-activators YAP and TAZ (transcriptional co-activator with PDZ domain)71,72.