CKB and liver cancer: In line with our observation, a randomised controlled trial among patients with non-alcoholic fatty liver disease showed that vigorous and moderate exercise reduced intrahepatic triglyceride content and the effect was largely mediated by weight loss.38 For liver cancer, the EPIC study showed that waist circumference explained 40% of the inverse associations for total physical activity,12 whereas waist circumference explained little of the inverse association in CKB.