Premature Ovarian Failure (POF), first described in the 1930s, is a clinical syndrome characterized by a loss of ovarian function before the age of 40 [2] with three sequential stages called occult, biochemical and clinical [3]; corresponding to fertility decline, then an increase in Follicle Stimulating Hormone (FSH) release rate (twice), and finally oligo or amenorrhea [4] respectively. This evidence concerns the gene BRD2 and premature menopause.