FOXO3 and breast cancer: Although Dr. Hu and colleagues administered low-dose metformin (0.1 mM or 0.01 mM) to suppress ovarian and breast cancer cell growth and survival in vitro, the aim of their study was to investigate whether low-dose metformin reprograms these cancer cells into noncancerous cells in a FOXO3-dependent manner, which may allow patients to successfully overcome these cancers with minimal side effects.