VEGFA and retinopathy of prematurity: Moreover, ROP’s second phase consists of (i) retinal vasoproliferation induced by hypoxia and an increased metabolic requirement [12,16], (ii) greater production of hormones (IGF-1) and growth factors (VEGF) to improve retinal perfusion in response to hypoxia [15,16,17], (iii) production of adhesive fibrins influenced by proteins of the extracellular matrix (vitronectin, fibronectin, and fibrinogen) [12,17], and (iv) induction of cellular processes such as growth, differentiation, and migration on endothelial cells (Figure 1) [12,13,14,15,16,17].