Subsequently, multiple case series and single site retrospective studies suggested that, in spite of the multitude of consequences of CFTR dysfunction, some women with CF could successfully navigate pregnancy and motherhood, although lower lung function (as measured by percent-predicted forced expiratory volume in 1 s [ppFEV1]), infection with certain gram negative infections, such as the Burkholderia cepacia complex, and the complication of cystic fibrosis related diabetes (CFRD), were associated with increased risk [6,7,8,9,10,11] (Figure 2). This evidence concerns the gene CFTR and cystic fibrosis-related diabetes.