CFTR and pregnancy disorder: Although the U.S. Cystic Fibrosis Foundation Patient Registry (CFFPR) collects data regarding the use of CFTR modulators, it does not collect data on infants born to mothers of CF; thus, it is not possible to determine from the U.S. CFFPR [3] the rate of congenital malformations in infants born to women with CF in general nor the rate of congenital malformation in infants in association with CFTR modulator use.