The proposed mechanisms able to explain lymphopenia are related to several mechanisms, such as direct infection through the receptor ACE2, a potential direct attack on the lymphatic organs, lymphocytic apoptosis due to the exposition to high levels of Tumour Necrosis Factor-α and Interleukin-6 or their inhibition caused by metabolic disorders as lactic acidemia [14]. The gene discussed is ACE2; the disease is metabolic disease.