INS and obesity due to melanocortin 4 receptor deficiency: The anti-oxidative, anti-obesity, and anti-diabetic potential of BCB was checked in the various diabetic model mice (Table 1), where BCB increased serum insulin secretion with reduced pro-inflammatory cytokine expression (MAPKs, NF-κB, COX-2, and iNOS) in a dose-dependent manner [183].