MBEs in HFD-fed male Sprague-Dawley rats prevented non-alcoholic fatty liver disease (NAFLD) by downregulating lipid/cholesterol homeostasis-related genes (FAS, ACC, GPAT, and SREBP-1) and suppressing the lipid oxidation biomarkers MDA and 4-hydroxynonenal [105,106]. This evidence concerns the gene ACACA and metabolic dysfunction-associated steatotic liver disease.