MAPK3 and cancer: Anticancer activity of CAPE has earlier been assigned to its several mechanisms of action including activation of tumor suppressor and apoptotic activities of p53 protein [11,18,28,30,62,63], modulation of the redox state of cells [64], restoration of gap junctional intercellular communication [65], inhibition of VEGF-induced angiogenesis [66], inhibition of EMT [67], radio- and chemo-sensitization of cancer cells [16,68,69], inhibition of inflammation signaling [70], activation of MAPK-ERK1/2 signaling [71] and inactivation of oncogenic PAK1 signaling [72].