In POAG, it is most likely that genetic or aging related gene expression changes to CDKN2B-AS1-CDKN2B axis may lead to cellular senescence associated alteration in secretome and cytokines, which leads to increase TGFβ1 signaling mediated senescent-inflammatory phenotype or vice versa (Figure 6). This evidence concerns the gene PTGDR and open-angle glaucoma.