Genome-wide association studies (GWAS) and candidate gene screening studies have identified the association of many genes including myocilin (MYOC), optineurin (OPTN), WD repeat domain 36 (WDR36), neurotrophic factor 4 (NTF4) and ankyrin repeat and SOCS box containing 10 (ASB10) with POAG and its endophenotypic traits [6,7,8,9,10,11,12]. The gene discussed is NTF4; the disease is open-angle glaucoma.