MOG and cancer: The gemini cationic lipid with functionalized histidine groups in its structure, C3(C16His)2, in combination with the neutral helper lipid MOG (α = 0.2), has demonstrated in this work its potential to compact, protect and transfect siRNA in two GFP over-expressing cancer cell lines (HeLa-GFP and T731-GFP), provoking in turn the GFP knockdown with efficiency and cell-safety.