CYP51A1 and infection: Since both HMGR and CYP51 are ‘druggable’ targets in A. castellanii [16,24] and isavuconazole suppressed excystment of Acanthamoeba cysts into trophozoites [20], it is possible that combination of pitavastatin and isavuconazole at lower concentrations may also prevent recurrence of infection caused by Acanthamoeba excystment.