Since both HMGR and CYP51 are ‘druggable’ targets in A. castellanii [16,24] and isavuconazole suppressed excystment of Acanthamoeba cysts into trophozoites [20], it is possible that combination of pitavastatin and isavuconazole at lower concentrations may also prevent recurrence of infection caused by Acanthamoeba excystment. The gene discussed is HMGA1; the disease is infection.