Antiphospholipid syndrome (APS, or Hughes syndrome) is a systemic autoantibody-mediated acquired thrombophilia that is characterized by the presence of antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins, such as beta-2-glycoprotein I (b2GPI) [43,44,45,46]. This evidence concerns the gene APOH and acute promyelocytic leukemia.