In H9c2 cardiomyocytes with increased activity of xanthine/xanthine oxidase (X/XO), which represent a risk factor for heart disease, HT treatment (0.1 and 10 μg/mL, for 24 h) induced a reduction in intracellular ROS level and a modulation of stress-sensitive pathways across the upregulation of defensive proteins, p44/42-MAPK and Hsp27 via c-Jun [51]. Here, XDH is linked to heart disorder.