CD8A and neoplasm: The induction of immune death by RT is thought to result in the release of tumour-associated antigens and DNA into the local TME, resulting in increased interferon type 1 (IFN-1) via the cGAS/STING pathway, promoting antigen presentation by BATF3-dendritic cells to prime the immune response and driving the recruitment and expansion of local CD8+ T-cells [19].