B-cells are capable of stimulating tumour-specific T-cells via IL-2, IL-4, IFN-γ and TNFα and by acting as specialised antigen presenting cells (APCs), differentiating into plasma cells, producing tumour-specific immunoglobulin, activating complement and promoting antibody-dependent, cell-mediated cytotoxicity (ADCC) [32]. Here, TNF is linked to neoplasm.