ZFYVE27 and melanoma: It might be more than a coincidence that protrudin binds via its FFAT motif (FFAT being an acronym for two phenylalanines (FF) in an Acidic Tract) to type II membrane protein VAP-A, and the knockdown of the latter impeded the subcellular localization of Rab7+ late endosomes in NEI of melanoma cells [160].