Though, other alterations in genes related to the MAPK pathway are frequently observed, including NF1, CBL, ERBB2, MAP2K1, and MAP3K1. Amplifications in EGFR, CDK4, MDM2, TERT, MAP3K1, MET, NFKBIE, and YAP1 are also commonly found in this melanoma subtype [34,67,68]. This evidence concerns the gene MAP3K1 and melanoma.