Among 18 PTC patients with lymph node metastasis–10 samples harboured BRAFV600E mutation (described later as “Metastatic- BRAF V600E (+)”), and 8 were BRAFV600E negative (“Metastatic–BRAF V600E (−)”). The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.