E2 and 4,4’,4’’-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), a selective agonist of ER-α, increased the number of cells derived from human GBM [45], while ER-β-specific agonists decreased GBM cell proliferation [44]. This evidence concerns the gene ESR1 and glioblastoma.