Although this topic is not yet well studied in GBM, in breast cancer, it has been determined in more detail that in the most malignant tumors with multiple metastases, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) represses ER-α transcription through the enhancer of zeste homolog2 (EZH2), which negatively regulates ER-α transcription [82]. This evidence concerns the gene ESR1 and breast carcinoma.