Although this topic is not yet well studied in GBM, in breast cancer, it has been determined in more detail that in the most malignant tumors with multiple metastases, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) represses ER-α transcription through the enhancer of zeste homolog2 (EZH2), which negatively regulates ER-α transcription [82]. The gene discussed is ESR1; the disease is cancer.