In literature, numerous variations of coagulation disorders have been the subject of investigation, but only antiphospholipid syndrome showed a strong correlation with RM [43], while results on the role of other thrombophilic defects, namely Factor V Leiden, prothrombin deficiency, antithrombin III deficiency, protein C deficiency and protein S deficiency, were conflicting [44,45]. Here, PROS1 is linked to blood coagulation disease.