Functional analysis of gene ontology revealed that the predicted gene targets (3925; Supplementary Table S3) of HER2-associated miRNAs are mostly involved in transcription regulation, but also in cellular matrix organization, regulation of cell cycle or apoptosis; apart from cancer-associated pathways, the most altered signaling pathways included PI3-K-Akt, p53, and FoxO (Figure 2, Supplementary Table S4). This evidence concerns the gene TP53 and cancer.