Compared to cutaneous, acral and mucosal melanoma, there was no enrichment of mutations in the RTK/RAS signaling pathway, but frequent mutually exclusive mutations in the genes of the guanine nucleotide-binding protein subunits GNA11 and GNAQ in combination with either the splicing factor SF3B1 or the deubiquitinating enzyme BAP1 (Figure 3a,b). Here, SF3B1 is linked to mucosal melanoma.