TP53 and malignant colon neoplasm: Therefore the aim of the present study was to determine the cytotoxicity, anti-proliferative and apoptotic activity of 1,5-bis(4-hydroxy-3- methoxyphenyl)-1, 4-pentadiene-3-one which is MS13 on human primary (SW480) and metastatic (SW620) colon cancer cells carrying KRAS and p53 mutations and also undergone CIN.