CASP3 and colonic neoplasm: Another DAP, 1,5-bis (2-metoxyphenyl)-1,4-pentadiene-3-one (B63) was shown to induce apoptosis in human colon cancer cells via the mitochondrial apoptotic pathway which includes down-regulation of mitochondrial complexes, up-regulation of pro-apoptotic proteins-Bad and Bim, activation of caspase-3, PARP cleavage and cytochrome c release [119].