In addition, Yoshida et al. (2018) reported that GO-Y022, a DAP with a similar structure to MS13, was able to suppress gastric tumor growth in transgenic mice (K19-Wnt/C2mE), inhibit phosphorylation of STAT3 without hepatic and renal toxicity, retain localized in tumor areas, as well as exhibit better pharmacokinetic profiles than curcumin [44] when ingested orally [66]. This evidence concerns the gene STAT3 and neoplasm.