CASP3 and cancer: It was reported that DAPs demonstrated anti-cancer effect through induction of apoptosis in various human colon cancer cell lines involving activation of caspase-3 [28,39,114,115] and down-regulation of anti-apoptotic Bcl-2 protein [116,117] even at a very low concentration between the range of 2.5–6.0 μM [45,117].