TP53 and colorectal carcinoma: Dysregulation in apoptosis pathways may include alteration of genes responsible in apoptosis modulation such as KRAS and TP53. It has been reported that about 30% of CRC cases were linked to KRAS oncogene mutations [94] and about 70% were linked to the p53 mutations [95,96,97], where involvement includes cell survival, proliferation, and dysregulation of apoptosis [94,98,99,100].