In particular, tumor microenvironment-derived-IL-1 promotes: (a) proliferation and survival by sustaining the production of ROS, NO and mutation occurrence; (b) metastasis dissemination by fostering the expression of adhesion molecules like I-CAM and V-CAM; (c) angiogenetic switch by increasing the production of cytokine, chemokines and facilitating endothelial permeability; (d) the activation of anti-apoptotic signals, which rescue apoptotic cells from death. The gene discussed is IL1A; the disease is neoplasm.