PTPA and leukemia: During the original description of 14,15-dihydro-DTX1, this compound was reported to be equally potent as compared to OA and DTX1 using a cytotoxicity assay against L-1210 leukemia cells [23], but in other studies looking at the relative inhibitory potencies of various OA-derivatives, including 14,15-dihydro-OA, this compound was reported to have a higher dissociation constant (lower affinity) for both PP1 and PP2A, isolated from rabbit skeletal muscle, compared to OA and DTX1 [22].