The antiproliferative activity of the compounds was investigated against doxorubicin-sensitive (Colo 205), multidrug-resistant (Colo 320, overexpressing ABCB1 (MDR1)-LRP) human colon adenocarcinoma, neuroblastoma (SH-SY5Y) cell lines and the non-cancerous human embryonal lung fibroblast cell line (MRC-5). The gene discussed is ABCB1; the disease is colon adenocarcinoma.