Next, because in cancer cells aerobic glycolysis (Warburg effect) becomes the major metabolic pathway generating lactate at the expense of oxidative phosphorylation [21], we analyzed the expression of genes implicated in lactate metabolism and observed an increase in the expression of genes involved in lactate production: lactate dehydrogenase A (Ldha), release: monocarboxylate transporter 4 (Mct4), uptake: monocarboxylate transporter 1 (Mct1), and metabolism: lactate dehydrogenase B (Ldhb) in PyMTTg; MMP11Tg mice as compared to controls (Figure 4Ba) [25,26]. The gene discussed is SLC16A1; the disease is cancer.