The further sections herein try to establish a descriptive line, detailing the importance of inositols and their derivatives, such as inositol-(phospho)glycans (IPGs or simply IGs) in physiological processes, highlighting their role in insulin signaling, as well as their function in the central nervous system and the perspective of their use in the treatment of neurodegenerative diseases, with a special emphasis on AD and behavioral disorders here. This evidence concerns the gene INS and neurodegenerative disease.