DCI uptake via SMIT2 is highly upregulated in the presence of insulin in human L6 myoblasts, which could explain the lower concentration of DCI in insulin-sensitive tissues and lower DCI re-uptake in the renal tubes in cases of hyperglycemia and insulin resistance [46,50,51], along with decreased epimerase activity [15,16]. This evidence concerns the gene INS and Hyperglycemia.