Regarding these findings, it is noteworthy that the action of BDNF bypasses the benefits related to the brain; it is involved in of metabolic functions regulation, such as fat oxidation and glucose uptake, thus, it is understood that it can be negatively regulated in those with obesity and type 2 diabetes [4,36,37]. The gene discussed is BDNF; the disease is obesity due to melanocortin 4 receptor deficiency.